Overview

ChIP Sequencing (ChIP-seq) is a method of sequencing that combines chromatin immunoprecipitation (ChIP) with sequencing to study DNA-protein interactions. This method is to disclose the specific location of DNA bound to the associated proteins throughout the genome. It is able to provide more information about the interactions between proteins and DNA and the influence of these interactions in biological processes. It helps us study gene regulation and transcriptional regulation events that are involved in various diseases and biological pathways.

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Applications

• Study DNA-binding proteins and map protein interaction sites across the entire genome to understand the gene regulation.

• Understand the epigenetic regulation of genes and identify regulatory elements like enhancers and promoters.

• Disclose how mutations in transcription factors or changes in histone modifications contribute to different diseases.

• Disclose the potential biomarkers related to disease progression by studying the binding sites of proteins involved in diseases.

• Map gene expression in different types of cells and different developmental stages.

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